Determinants of Isoniazid Preventive Therapy Completion among People Living with HIV in Oyo and Ogun States, Southwest Nigeria

Abstract

Background: The World Health Organization (WHO) recommends the use of Isoniazid Preventive Therapy (IPT) among People Living with HIV (PLHIV) to reduce morbidity and mortality from Tuberculosis (TB). This study assessed the rate of IPT completion and its associated factors among PLHIV in South West Nigeria.
Methods: A review of records of 1526 PLHIV who commenced IPT between October 2017 and December 2018 was done. Data were extracted from facility level IPT service documentation tools using study-developed data abstraction template. The chi-square  test was used to assess the association between the independent variables and the patient’s IPT completion status at 0.05 significance level. Logistic regression was used to determine the predictors of IPT completion.
Results: The mean age of the study population was 42.3±11.3 years and 1154 (75.6%) of them were females. About 1342 (87.9%) completed IPT within six months of initiation. Major reasons for non-completion of IPT were lost to follow up 86 (46.7%) and nonadherence to IPT 60 (32.6%). Higher proportion of respondents who were Igbo (92.9%), ART-naïve (97.6%) or active on ART regimen (94.8%) completed their IPT regimen within 6 months of initiation when compared to those of other tribes (p=0.023), ART experienced (87.7%), (p=0.023) or inactive on treatment (0.9%), (p<0.001) respectively. Traders/farmers were 6 times more likely to complete IPT compared to public/civil servants (AOR=6.110, 95%CI=2.180-17.112, p=0.001).
Conclusion: IPT completion rate was high among study participants. Intensified counselling on IPT benefits among ART patients with focus on civil/public servants might further improve IPT completion.

Keywords: IPT Completion; Isoniazid Preventive Therapy; PLHIV; Tuberculosis; Southwest Nigeria